Spray formulation of clonidine HCl minimize the limitation of conventional oral and transdermal preparation like gastric irritation, first pass metabolism, and skin redness or skin irritation of transdermal patch system. Clonidine HCl is an active ingredient of the invention which has been used from many years as an antihypertensive agent in treatment of long term hypertension. The aim of the study is preliminary investigation of the the metered spray. In screening work, Concentration of penetration enhancers (octyl salicylate and tulsi oil), drug concentration were selected. And study indicates that octyl salicylate is better penetration enhancer and at higher drug concentration diffusion of drug is higher. By using central composite design 13 formulation were prepared and filled in aerosol contairs with propellant and primarily investigated for different evaluation tests.
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